Description

PEG (Acetic Acid)2 (PEG di-acetic acid or PEG dicarboxyl) with superior quality specification of ≥95% Substitution.

PEG (Acetic Acid)2 from JenKem Technology is a homobifunctional PEG employed for amine pegylation and crosslinking, reactive towards the amine group of lysine(s). Homobifunctional PEG derivatives from JenKem Technology have numerous applications as crosslinkers for PEGylation of proteins and peptides, nanoparticle and surface modifications. Conjugation with homobifunctional PEGs ensures an increased drug load compared to pegylation with linear PEGs. JenKem Technology offers Acetic Acid PEG Acetic Acid with MW 2,000 Da (CM-PEG2000-CM), MW 3,500 Da (CM-PEG3500-CM), MW 5,000 Da (CM-PEG5000-CM), and MW 7,500 Da (CM-PEG7500-CM), in 1g and 5g packing sizes.

Different MW of PEG (Acetic Acid)2 may be available by custom synthesis, please email us at tech@jenkemusa.com for details on custom PEGs. JenKem Technology provides repackaging services for an additional fee, please contact us if you require a different package size than our catalog selection.

Bulk PEGs and GMP grade PEGs are made-to-order. Please contact us for bulk pricing.

Note: Starting July 2016, PEG (Acetic Acid)2 is the new name of the product Carboxyl PEG Carboxyl (MW 2000 Da (COOH-PEG2000-COOH), MW 3500 Da (COOH-PEG3500-COOH), MW 5,000 Da (COOH-PEG5000-COOH), and MW 7500 Da (COOH-PEG7500-COOH); or PEG Dicarboxyl. JenKem Technology has revised the name of the product to better reflect the chemical structure, as many other PEG derivatives with COOH group are offered in the catalog.

References:

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3. Xiao, S., et al., Aptamer-mediated gene therapy enhanced antitumor activity against human hepatocellular carcinoma in vitro and in vivo, Journal of Controlled Release, 2017.
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5. Lorenzo, M. M., et al., Homodimeric Protein–Polymer Conjugates via the Tetrazine–trans-Cyclooctene Ligation, Macromolecules, 2015.
6. Xue, Y., et al., Quantifying thiol–gold interactions towards the efficient strength control, Nature communications, 2014, 5.
7. Xu, P., et al., Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis. Biomaterials, 2014, 35(26): p. 7574-7587.
8. Gajbhiye, V., et al., Drug-loaded nanoparticles induce gene expression in human pluripotent stem cell derivatives. Nanoscale, 2014, 6(1): p. 521-31.
9. Gao, X., et al., Prostate stem cell antigen-targeted nanoparticles with dual functional properties: in vivo imaging and cancer chemotherapy. Int J Nanomedicine, 2012, 7: p. 4037-51.

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.

JenKem Technology由PEG合成和PEG化的专家成立于2001年，专门从事高纯度，低多分散性的聚乙二醇（PEG）衍生物，PEG共聚物，单分散PEG，定制PEG衍生物合成和PEG化服务。通过获得本体环氧乙烷以及内部所有聚合和衍生化的性能来支持特定的强度。

JenKem Technology从研发到GMP商业批量提供全球PEG衍生物，用于临床前，临床试验以及用于制药，生物技术，医疗设备和诊断的商业产品。