Description

PEG (Succinimidyl Carboxymethyl Ester)2 with superior quality specification of ≥95% Substitution.

JenKem Technology’s PEG (Succinimidyl Carboxymethyl Ester)2 (SCM-PEG-SCM, NHS PEG NHS, PEG diNHS, or PEG diSCM) is a high quality amine reactive homofunctional PEG product with a stable non-degradable linker between the PEG polymeric chain and the NHS ester. The Succinimidyl Carboxymethyl Ester group reacts with the amine group of lysine(s) at room temperature at pH 7-8. JenKem Technology’s homobifunctional PEG derivatives have numerous applications as crosslinkers, including for PEGylation of proteins and peptides, nanoparticle and surface modifications. Conjugation with homobifunctional PEGs provides an increased drug load compared to pegylation using linear PEGs.

JenKem Technology offers PEG diSCM Ester with MW 2kDa (SCM-PEG2000-SCM), MW 3.5 kDa (SCM-PEG3500-SCM), MW 5kDa (SCM-PEG5000-SCM), MW 7.5kDa (SCM-PEG7500-SCM), in 1g and 5g packing sizes. Different MW of PEG diSCM homobifunctional products may be available by custom synthesis, please email us at tech@jenkemusa.com for details on custom PEGs. JenKem Technology provides repackaging services for an additional fee, please contact us if you require a different package size than our catalog selection.

Bulk PEGs and GMP grade PEGs are made-to-order. Please contact us for bulk pricing.

Click here to download the MSDS

References:

1. Lu, C., et al., Poly(ethylene glycol) crosslinked multi-armed poly(ε-benzyloxycarbonyl-L-lysine)s as super-amphiphiles: Synthesis, self-assembly, and evaluation as efficient delivery systems for poorly water-soluble drugs, Colloids and Surfaces B: Biointerfaces, 2019, 182.
2. Inostroza-Brito, K.E., et al., Cross-linking of a Biopolymer-Peptide Co-Assembling System, Acta Biomaterialia, 2017.
3. Walker, J.M., et al., Magnetically Triggered Radical-Generating Fe3O4 Nanoparticles for Biopolymer Restructuring: Application to the Extracellular Matrix, Chem. Mater., 2015, 27 (24), pp 8448–8456.
4. Zhou, J., et al., In vivo evaluation of medical device-associated inflammation using a macrophage-specific positron emission tomography (PET) imaging probe. Bioorganic & Medicinal Chemistry Letters, 2013, 23(7): p. 2044-2047.

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.

JenKem Technology由PEG合成和PEG化的专家成立于2001年，专门从事高纯度，低多分散性的聚乙二醇（PEG）衍生物，PEG共聚物，单分散PEG，定制PEG衍生物合成和PEG化服务。通过获得本体环氧乙烷以及内部所有聚合和衍生化的性能来支持特定的强度。

JenKem Technology从研发到GMP商业批量提供全球PEG衍生物，用于临床前，临床试验以及用于制药，生物技术，医疗设备和诊断的商业产品。