Description

Methoxy PEG Succinimidyl Carbonate for amine PEGylation, with superior quality specification of  ≥95% Substitution.

JenKem Technology’s Methoxy PEG Succinimidyl Carbonate (Methoxy PEG SC) is a high quality amine reactive NHS PEG product which reacts with the amine group of lysine(s) such as the lysines present on IFN, Interferon alpha 2b, by means of stable urethane linkages. Methoxy PEG Succinimidyl Carbonate has a longer hydrolysis half-life compared with M-PEG-SCM. JenKem Technology offers Methoxy PEG Succinimidyl Carbonate with MW 10000 Da (M-SC-10K), MW 12000 (M-SC-12K), and MW 20000 Da (M-SC-20K), in 1g and 10g packing sizes.

Different MW of Methoxy PEG Succinimidyl Carbonate products may be available by custom synthesis, please email us at tech@jenkemusa.com for details on custom PEGs. Other related linear Amine Reactive PEG products are available – please select linear carbonate PEGs;  cleavable linker NHS PEGs; or stable linker NHS PEGs. JenKem Technology provides repackaging services for an additional fee, please contact us if you require a different package size than our catalog selection.

Bulk PEGs and GMP grade PEGs are made-to-order. Please contact us for bulk pricing.

Click here to download the MSDS

References:

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3. Yan, J., et al., Tumor Contrast Imaging with Gas Vesicles by Circumventing the Reticuloendothelial System, Ultrasound in Medicine & Biology, 2020, V. 46(2); P. 359-368.
4. Vaillard, V.A., et al., mPEG–NHS carbonates: Effect of alkyl spacers on the reactivity: Kinetic and mechanistic insights, Journal of Applied Polymer Science, 2019, 136(5):47028.
5. Ma, S.S., et al., The pharmacokinetic and pharmacodynamic properties of site-specific pegylated genetically modified recombinant human interleukin-11 in normal and thrombocytopenic monkeys, European Journal of Pharmaceutics and Biopharmaceutics, 2017.
6. Zhao, Y.Z., et al., PEGylation with the thiosuccinimido butylamine linker significantly increases the stability of haloalkane dehalogenase DhaA, Journal of Biotechnology, 2017.
7. Lee, K., et al., Enhanced accumulation of theranostic nanoparticles in brain tumor by external magnetic field mediated in situ clustering of magnetic nanoparticles, Journal of Industrial and Engineering Chemistry, 2017.
8. Wan, X., et al., Effect of protein immunogenicity and PEG size and branching on the anti-PEG immune response to PEGylated proteins, Process Biochemistry, 2017, 52:183-91.
9. Fahrlander E., et al., PEGylated human serum albumin (HSA) nanoparticles: preparation, characterization and quantification of the PEGylation extent, Nanotechnology, 2015, 26(14):145103.
10. Zhang, J., et al., Magnetic Targeting of Novel Heparinized Iron Oxide Nanoparticles Evaluated in a 9L-glioma Mouse Model, Pharmaceutical Research, 2014, 31:3, pp 579-592.
11. Peng, F., et al., PEGylation of G-CSF in organic solvent markedly increase the efficacy and reactivity through protein unfolding, hydrolysis inhibition and solvent effect. Journal of Biotechnology, 2014, 170: p. 42-49.
12. Mingji Jin, et al, Preparation of pegylated lumbrokinase and an evaluation of its thrombolytic activity both in vitro and in vivo, Acta Pharmaceutica Sinica B, 2013, 3(2) p: 123-129.
13. Zhang, J., et al., Long-Circulating Heparin-Functionalized Magnetic Nanoparticles for Potential Application as a Protein Drug Delivery Platform, Molecular Pharmaceutics, 2013, 10(10), 3892-3902.
14. Jun Wang, et al., An oriented adsorption strategy for efficient solid phase PEGylation of recombinant staphylokinase by immobilized metal-ion affinity chromatography, Process Biochemistry, 2012, 47, 1,  p: 106-112.
15. Liu, S.. et al., Mono-PEGylation of ribonuclease A: High PEGylation efficiency by thiolation with small molecular weight reagent, Process Biochemistry, 2012, 47(9),  p: 1364-1370.
16. Peng, F., et al., PEGylation of Proteins in Organic Solution: A Case Study for Interferon beta-1b, Bioconjugate Chem., 2012, 23 (9), 1812-1820.
17. Beibei, H., Design, Preparation and in vitro Bioactivity of Mono-PEGylated Recombinant Hirudin, Chin. J. Chem. Eng., 2007, 15(6) 775—780.

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization directly from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.

JenKem Technology由PEG合成和PEG化的专家成立于2001年，专门从事高纯度，低多分散性的聚乙二醇（PEG）衍生物，PEG共聚物，单分散PEG，定制PEG衍生物合成和PEG化服务。通过获得本体环氧乙烷以及内部所有聚合和衍生化的性能来支持特定的强度。

JenKem Technology从研发到GMP商业批量提供全球PEG衍生物，用于临床前，临床试验以及用于制药，生物技术，医疗设备和诊断的商业产品。