Description

Monodisperse Acetic Acid PEG8 Acetic Acid reagent with superior quality specification of ≥ 95% Purity.

Monodisperse Acetic Acid PEG8 Acetic Acid from JenKem Technology (a.k.a. discrete diCarboxy PEG8, Carboxyl PEG8 Carboxyl, diAcetic Acid PEG8, diCM PEG8, diCarboxylPEG8 or diAA PEG8) is a single molecule homobifunctional PEG employed for amine PEGylation.  Monodisperse homobifunctional PEG derivatives from JenKem Technology are high quality crosslinkers for PEGylation of proteins and peptides, nanoparticle and surface modifications. Conjugation with homobifunctional PEGs provides an increased drug load compared to PEGylation using linear PEGs. JenKem Technology’s monodisperse Carboxyl PEG Carboxyl products are produced via very reproducible chemical reactions and lack the polydispersity of traditional PEG polymers. JenKem’s monodisperse Carboxyl PEG Carboxyl retain the polyethylene glycol’s good solubility in water, while offering to PEGylated drugs the same PEG benefits of reduced aggregation and immunogenicity, and increased hydrodynamic volume.

JenKem Technology offers monodisperse Acetic Acid PEG8 Acetic Acid with MW 486.5 Da (CM-PEG8-CM) and cetic Acid PEG12 Acetic Acid with MW 662.7 Da (CM-PEG12-CM), in 1g and 5g packing sizes.  Discrete PEG diCarboxyl with different numbers of -CH2-CH2-O- units, such as Acetic Acid PEG4 Acetic Acid (CM-PEG4-CM) may be available by custom synthesis, please email us at tech@jenkemusa.com for details on custom PEGs. JenKem Technology provides repackaging services for an additional fee, please contact us if you require a different package size than our catalog selection.

Bulk PEGs and GMP grade PEGs are made-to-order. Please contact us for bulk pricing.

References:

1. Xu, P., et al., Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis. Biomaterials, 2014. 35(26): p. 7574-7587.

2. Gajbhiye, V., et al., Drug-loaded nanoparticles induce gene expression in human pluripotent stem cell derivatives. Nanoscale, 2014. 6(1): p. 521-31.

3. Gao, X., et al., Prostate stem cell antigen-targeted nanoparticles with dual functional properties: in vivo imaging and cancer chemotherapy. Int J Nanomedicine, 2012. 7: p. 4037-51.

Note: Starting July 2016, Acetic Acid PEG Acetic Acid is the new name of the product Carboxyl PEG Carboxyl (MW 486.5 (CM-PEG8-CM), MW 662.7 (CM-PEG12-CM)). JenKem Technology has revised the name of the product to better reflect the chemical structure, as many different PEG derivatives with a COOH group are offered in the 2016 JenKem USA catalog.

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom polymer synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization directly from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.

JenKem Technology由PEG合成和PEG化的专家成立于2001年，专门从事高纯度，低多分散性的聚乙二醇（PEG）衍生物，PEG共聚物，单分散PEG，定制PEG衍生物合成和PEG化服务。通过获得本体环氧乙烷以及内部所有聚合和衍生化的性能来支持特定的强度。

JenKem Technology从研发到GMP商业批量提供全球PEG衍生物，用于临床前，临床试验以及用于制药，生物技术，医疗设备和诊断的商业产品。